教員情報 - 大海　雄介

オオウミ　ユウスケ OHMI Yuhsuke
大海　雄介

所属

生命健康科学部臨床工学科

臨地実習推進部臨床工学実習センター

職名講師

著書・論文歴
論文	Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin. The Journal of cell biology 224 (6) (共著) 2025/06
論文	GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics. Cancer science 116 (4),862-870 (共著) 2025/04
論文	Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins. International journal of molecular sciences 25 (23) (共著) 2024/11
論文	Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance. iScience 27 (11),111139 (共著) 2024/11
論文	Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells. Nagoya journal of medical science 86 (3),435-451 (共著) 2024/08
論文	Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT. BMC genomics 25 (1),568 (共著) 2024/06
論文	Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells. Glycoconjugate journal 40 (3),323-332 (共著) 2023/06
論文	Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene. FEBS open bio (共著) 2023/03/31
論文	Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells Glycoconjugate Journal 40 (3),323-332頁 (共著) 2023/03/10
論文	Extracellular vesicles released from ganglioside GD2-expressing melanoma cells enhance the malignant properties of GD2-negative melanomas. Scientific reports 13 (1),4987 (共著) 2023/03
論文	Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway. PloS one 18 (2),e0281414 (共著) 2023
論文	Functional validation of novel variants in B4GALNT1 associated with early-onset complex hereditary spastic paraplegia with impaired ganglioside synthesis. American journal of medical genetics. Part A 188 (9),2590-2598 (共著) 2022/09
論文	Functional validation of novel variants in <scp> B4GALNT1 </scp> associated with early‐onset complex hereditary spastic paraplegia with impaired ganglioside synthesis American Journal of Medical Genetics Part A (共著) 2022/07
論文	Signaling domains of cancer-associated glycolipids. Glycoconjugate journal 39 (2),145-155頁 (共著) 2022/04
論文	Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins International Journal of Molecular Sciences 23 (1),423-423頁 (共著) 2021/12/31
論文	Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins. International journal of molecular sciences 23 (1) (共著) 2021/12
論文	Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model. Cancer science 112 (9),3756-3768 (共著) 2021/09
論文	St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity. Nagoya journal of medical science 83 (3),535-549頁 (共著) 2021/08
論文	Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model Cancer Science (共著) 2021/06/30
論文	Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes. Glycobiology 31 (5),557-570 (共著) 2021/06
論文	Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Research 41 (4),1821-1830頁 (共著) 2021/04
論文	Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling. Anticancer research 41 (4),1821-1830 (共著) 2021/04
論文	Majority of alpha2,6-sialylated glycans in the adult mouse brain exist inO-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes Glycobiology (共著) 2020/11/25
論文	Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia. Journal of biochemistry 168 (2),103-112頁 (共著) 2020/04/13
論文	Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering. International journal of molecular sciences 21 (6) (共著) 2020/03/11
論文	マウス脳由来細胞におけるインフルエンザウイルス-糖鎖相互作用の解析日本薬学会年会要旨集 140年会,28P-am090頁 (共著) 2020/03
論文	グリオーマの微小環境調節におけるガングリオシドGD3の役割(Roles of ganglioside GD3 in the regulation of microenvironment of gliomas) 日本癌学会総会記事 78回,E-1029頁 (共著) 2019/09
論文	Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies. Nature communications 10 (1),3883-3883頁 (共著) 2019/08/28
論文	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface. The Journal of biological chemistry 294 (28),10833-10845頁 (共著) 2019/07/12
論文	New era of research on cancer-associated glycosphingolipids. Cancer science 110 (5),1544-1551頁 (共著) 2019/05
論文	Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice. Neuroscience 397,94-106頁 (共著) 2019/01/15
論文	Technologies to elucidate functions of glycans Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG),87-124頁 (共著) 2019/01/01
論文	Elucidation of the enigma of glycosphingolipids in the regulation of inflammation and degeneration - Great progress over the last 70 years. Proceedings of the Japan Academy. Series B, Physical and biological sciences 95 (3),136-149頁 (共著) 2019
論文	Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS biology 16 (11),e2006951 (共著) 2018/11
論文	Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2. International journal of oncology 52 (4),1255-1266頁 (共著) 2018/04
論文	ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer. Cancer science 109 (1),141-153頁 (共著) 2018/01
論文	Differential roles of gangliosides in malignant properties of melanomas. PloS one 13 (11),e0206881 (共著) 2018
論文	Gangliosides in Inflammation and Neurodegeneration. Progress in molecular biology and translational science 156,265-287頁 (共著) 2018
論文	Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis. Biochimica et biophysica acta. General subjects 1861 (10),2479-2484頁 (共著) 2017/10
論文	Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochemical and biophysical research communications 479 (3),453-460頁 (共著) 2016/10/21
論文	Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Scientific reports 6,34505-34505頁 (共著) 2016/09/30
論文	Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes. Glycobiology 26 (9),984-998頁 (共著) 2016/09
論文	Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells. The Journal of biological chemistry 291 (32),16630-43頁 (共著) 2016/08/05
論文	A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3. Biochimica et biophysica acta 1860 (8),1753-63頁 (共著) 2016/08
論文	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Nature communications 7,11205-11205頁 (共著) 2016/04/05
論文	Regulatory mechanisms for malignant properties of cancer cells with disialyl and monosialyl gangliosides Glycosignals in Cancer: Mechanisms of Malignant Phenotypes,57-76頁 (共著) 2016/01/01
論文	Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase. The Journal of biological chemistry 290 (26),16043-58頁 (共著) 2015/06/26
論文	b-Series gangliosides crucially regulate leptin secretion in adipose tissues. Biochemical and biophysical research communications 459 (2),189-195頁 (共著) 2015/04/03
論文	Regulatory function of glycosphingolipids in the inflammation and degeneration. Archives of biochemistry and biophysics 571,58-65頁 (共著) 2015/04/01
論文	Gangliosides: Synthesis and function in nervous tissues Glycoscience: Biology and Medicine,551-556頁 (共著) 2015/01/01
論文	Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord. Journal of neuroinflammation 11,61-61頁 (共著) 2014/03/28
論文	Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 34 (3),880-91頁 (共著) 2014/01/15
論文	Beta-1,4 N-Acetylgalactosaminyltransferase 1,2 (B4GALNT1,2) Handbook of Glycosyltransferases and Related Genes, Second Edition 1,417-428頁 (共著) 2014/01/01
論文	UDP-gal: BetaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (B3GALT4) Handbook of Glycosyltransferases and Related Genes, Second Edition 1,81-88頁 (共著) 2014/01/01
論文	Disialyl gangliosides enhance tumor phenotypes with differential modalities. Glycoconjugate journal 29 (8-9),579-84頁 (共著) 2012/12
論文	Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues. Neurochemical research 37 (6),1185-91頁 (共著) 2012/06
論文	Fine tuning of cell signals by glycosylation. Journal of biochemistry 151 (6),573-8頁 (共著) 2012/06
論文	C9-R95X polymorphism in patients with neovascular age-related macular degeneration. Investigative ophthalmology & visual science 53 (1),508-12頁 (共著) 2012/01/31
論文	Regulatory mechanisms of nervous systems with glycosphingolipids. Neurochemical research 36 (9),1578-86頁 (共著) 2011/09
論文	Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling. Biochemical and biophysical research communications 411 (3),483-9頁 (共著) 2011/08/05
論文	STRONG ANTIBODY REACTION AGAINST GLYCOSPHINGOLIPIDS INJECTED IN LIPOSOME-EMBEDDED FORMS IN beta 3GN-T5 KNOCKOUT MICE NAGOYA JOURNAL OF MEDICAL SCIENCE 73 (3-4),137-146頁 (共著) 2011/08
論文	Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice. Nagoya journal of medical science 73 (3-4),137-46頁 (共著) 2011/08
論文	[Molecular mechanisms for the regulation of nervous systems with glycosphingolipids]. Seikagaku. The Journal of Japanese Biochemical Society 83 (3),169-78頁 (共著) 2011/03
論文	Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice. Journal of neurochemistry 116 (5),926-35頁 (共著) 2011/03
論文	GM2/GD2合成酵素遺伝子の破壊によりTis21にかかわりなく9-O-アセチルGD3が明らかに発現する(Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回 (3),4P-0073頁 (共著) 2010/12
論文	GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. Cancer science 101 (9),2039-47頁 (共著) 2010/09
論文	Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. The Journal of biological chemistry 285 (35),27213-23頁 (共著) 2010/08/27
論文	Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. Behavioural brain research 206 (1),101-8頁 (共著) 2010/01/05
論文	Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proceedings of the National Academy of Sciences of the United States of America 106 (52),22405-10頁 (共著) 2009/12/29
論文	Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Behavioural brain research 198 (1),74-82頁 (共著) 2009/03/02
論文	Impaired hypoglossal nerve regeneration in mutant mice lacking complex gangliosides: down-regulation of neurotrophic factors and receptors as possible mechanisms. Glycobiology 18 (7),509-16頁 (共著) 2008/07
論文	Usefulness of repeated GenomiPhi, a phi29 DNA polymerase-based rolling circle amplification kit, for generation of large amounts of plasmid DNA. Biomolecular engineering 22 (4),129-32頁 (共著) 2005/10
論文	Direct subcloning of target region from BAC insert using restriction enzymes that produce non-identical cohesive ends. Nucleic acids symposium series (2004) (48),141-2頁 (共著) 2004
論文	Repeated GenomiPhi, phi29 DNA polymerase-based rolling circle amplification, is useful for generation of large amounts of plasmid DNA. Nucleic acids symposium series (2004) (48),147-8頁 (共著) 2004