Faculty - OHMI Yuhsuke |

OHMI Yuhsuke

Department / Course

College of Life and Health Sciences Department of Clinical Engineering

Office for the Coordination of Clinical Practicums Center for Clinical Engineering Practicum Support

Job Senior Assistant Professor

Book and thesis
Papers	Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene. FEBS open bio (Co-authored) 2023/03/31
Papers	Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells Glycoconjugate Journal,pp.323-332 (Co-authored) 2023/03/10
Papers	Functional validation of novel variants in <scp> B4GALNT1 </scp> associated with early‐onset complex hereditary spastic paraplegia with impaired ganglioside synthesis American Journal of Medical Genetics Part A (Co-authored) 2022/07
Papers	Signaling domains of cancer-associated glycolipids. Glycoconjugate journal 39 (2),pp.145-155 (Co-authored) 2022/04
Papers	Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins International Journal of Molecular Sciences,pp.423-423 (Co-authored) 2021/12/31
Papers	St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity. Nagoya journal of medical science 83 (3),pp.535-549 (Co-authored) 2021/08
Papers	Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model Cancer Science (Co-authored) 2021/06/30
Papers	Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Research,pp.1821-1830 (Co-authored) 2021/04
Papers	Majority of alpha2,6-sialylated glycans in the adult mouse brain exist inO-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes Glycobiology (Co-authored) 2020/11/25
Papers	Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia. Journal of biochemistry 168 (2),pp.103-112 (Co-authored) 2020/04/13
Papers	Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering. International journal of molecular sciences 21 (6) (Co-authored) 2020/03/11
Papers	グリオーマの微小環境調節におけるガングリオシドGD3の役割(Roles of ganglioside GD3 in the regulation of microenvironment of gliomas) 日本癌学会総会記事 78回,pp.E-1029 (Co-authored) 2019/09
Papers	Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies. Nature communications 10 (1),pp.3883-3883 (Co-authored) 2019/08/28
Papers	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface. The Journal of biological chemistry 294 (28),pp.10833-10845 (Co-authored) 2019/07/12
Papers	New era of research on cancer-associated glycosphingolipids. Cancer science 110 (5),pp.1544-1551 (Co-authored) 2019/05
Papers	Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice. Neuroscience 397,pp.94-106 (Co-authored) 2019/01/15
Papers	Technologies to elucidate functions of glycans Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG),pp.87-124 (Co-authored) 2019/01/01
Papers	Elucidation of the enigma of glycosphingolipids in the regulation of inflammation and degeneration - Great progress over the last 70 years. Proceedings of the Japan Academy. Series B, Physical and biological sciences 95 (3),pp.136-149 (Co-authored) 2019
Papers	Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS biology 16 (11),pp.e2006951 (Co-authored) 2018/11
Papers	Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2. International journal of oncology 52 (4),pp.1255-1266 (Co-authored) 2018/04
Papers	ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer. Cancer science 109 (1),pp.141-153 (Co-authored) 2018/01
Papers	Differential roles of gangliosides in malignant properties of melanomas. PloS one 13 (11),pp.e0206881 (Co-authored) 2018
Papers	Gangliosides in Inflammation and Neurodegeneration. Progress in molecular biology and translational science 156,pp.265-287 (Co-authored) 2018
Papers	Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis. Biochimica et biophysica acta. General subjects 1861 (10),pp.2479-2484 (Co-authored) 2017/10
Papers	Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochemical and biophysical research communications 479 (3),pp.453-460 (Co-authored) 2016/10/21
Papers	Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Scientific reports 6,pp.34505-34505 (Co-authored) 2016/09/30
Papers	Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes. Glycobiology 26 (9),pp.984-998 (Co-authored) 2016/09
Papers	Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells. The Journal of biological chemistry 291 (32),pp.16630-43 (Co-authored) 2016/08/05
Papers	A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3. Biochimica et biophysica acta 1860 (8),pp.1753-63 (Co-authored) 2016/08
Papers	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Nature communications 7,pp.11205-11205 (Co-authored) 2016/04/05
Papers	Regulatory mechanisms for malignant properties of cancer cells with disialyl and monosialyl gangliosides Glycosignals in Cancer: Mechanisms of Malignant Phenotypes,pp.57-76 (Co-authored) 2016/01/01
Papers	Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase. The Journal of biological chemistry 290 (26),pp.16043-58 (Co-authored) 2015/06/26
Papers	b-Series gangliosides crucially regulate leptin secretion in adipose tissues. Biochemical and biophysical research communications 459 (2),pp.189-195 (Co-authored) 2015/04/03
Papers	Regulatory function of glycosphingolipids in the inflammation and degeneration. Archives of biochemistry and biophysics 571,pp.58-65 (Co-authored) 2015/04/01
Papers	Gangliosides: Synthesis and function in nervous tissues Glycoscience: Biology and Medicine,pp.551-556 (Co-authored) 2015/01/01
Papers	Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord. Journal of neuroinflammation 11,pp.61-61 (Co-authored) 2014/03/28
Papers	Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 34 (3),pp.880-91 (Co-authored) 2014/01/15
Papers	Beta-1,4 N-Acetylgalactosaminyltransferase 1,2 (B4GALNT1,2) Handbook of Glycosyltransferases and Related Genes, Second Edition 1,pp.417-428 (Co-authored) 2014/01/01
Papers	UDP-gal: BetaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (B3GALT4) Handbook of Glycosyltransferases and Related Genes, Second Edition 1,pp.81-88 (Co-authored) 2014/01/01
Papers	Disialyl gangliosides enhance tumor phenotypes with differential modalities. Glycoconjugate journal 29 (8-9),pp.579-84 (Co-authored) 2012/12
Papers	Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues. Neurochemical research 37 (6),pp.1185-91 (Co-authored) 2012/06
Papers	Fine tuning of cell signals by glycosylation. Journal of biochemistry 151 (6),pp.573-8 (Co-authored) 2012/06
Papers	C9-R95X polymorphism in patients with neovascular age-related macular degeneration. Investigative ophthalmology & visual science 53 (1),pp.508-12 (Co-authored) 2012/01/31
Papers	Regulatory mechanisms of nervous systems with glycosphingolipids. Neurochemical research 36 (9),pp.1578-86 (Co-authored) 2011/09
Papers	Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling. Biochemical and biophysical research communications 411 (3),pp.483-9 (Co-authored) 2011/08/05
Papers	STRONG ANTIBODY REACTION AGAINST GLYCOSPHINGOLIPIDS INJECTED IN LIPOSOME-EMBEDDED FORMS IN beta 3GN-T5 KNOCKOUT MICE NAGOYA JOURNAL OF MEDICAL SCIENCE 73 (3-4),pp.137-146 (Co-authored) 2011/08
Papers	Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice. Nagoya journal of medical science 73 (3-4),pp.137-46 (Co-authored) 2011/08
Papers	[Molecular mechanisms for the regulation of nervous systems with glycosphingolipids]. Seikagaku. The Journal of Japanese Biochemical Society,pp.169-78 (Co-authored) 2011/03
Papers	Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice. Journal of neurochemistry 116 (5),pp.926-35 (Co-authored) 2011/03
Papers	GM2/GD2合成酵素遺伝子の破壊によりTis21にかかわりなく9-O-アセチルGD3が明らかに発現する(Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回 (3),pp.4P-0073 (Co-authored) 2010/12
Papers	GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. Cancer science 101 (9),pp.2039-47 (Co-authored) 2010/09
Papers	Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. The Journal of biological chemistry 285 (35),pp.27213-23 (Co-authored) 2010/08/27
Papers	Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. Behavioural brain research 206 (1),pp.101-8 (Co-authored) 2010/01/05
Papers	Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proceedings of the National Academy of Sciences of the United States of America 106 (52),pp.22405-10 (Co-authored) 2009/12/29
Papers	Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Behavioural brain research 198 (1),pp.74-82 (Co-authored) 2009/03/02
Papers	Impaired hypoglossal nerve regeneration in mutant mice lacking complex gangliosides: down-regulation of neurotrophic factors and receptors as possible mechanisms. Glycobiology 18 (7),pp.509-16 (Co-authored) 2008/07
Papers	Usefulness of repeated GenomiPhi, a phi29 DNA polymerase-based rolling circle amplification kit, for generation of large amounts of plasmid DNA. Biomolecular engineering 22 (4),pp.129-32 (Co-authored) 2005/10
Papers	Direct subcloning of target region from BAC insert using restriction enzymes that produce non-identical cohesive ends. Nucleic acids symposium series (2004) (48),pp.141-2 (Co-authored) 2004
Papers	Repeated GenomiPhi, phi29 DNA polymerase-based rolling circle amplification, is useful for generation of large amounts of plasmid DNA. Nucleic acids symposium series (2004) (48),pp.147-8 (Co-authored) 2004