Book and thesis
Papers
CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling. Journal of immunology (Baltimore, Md. : 1950) (Co-authored) 2024/02
Papers
REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response. Cancer science (Co-authored) 2023/12
Papers
Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift Cellular & Molecular Biology Letters (Co-authored) 2020/12
Papers
Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors. Cancer letters 489,pp.100-110 2020/10/01
Papers
Two-week continuous supplementation of hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study MEDICAL GAS RESEARCH 10 (4),pp.163-169 2020/10
Papers
Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study MEDICAL GAS RESEARCH 10 (3),pp.96-102 2020/07
Papers
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. Biochemical and biophysical research communications 525 (4),pp.1074-1080 2020/05/14
Papers
Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes. Nagoya journal of medical science 82 (2),pp.261-280 2020/05
Papers
Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993) 41 (4),pp.307-311 2019
Papers
BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Biochemistry and biophysics reports 15,pp.69-75 2018/09
Papers
Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles Free Radical Research 52 (4),pp.434-445 2018/04/03
Papers
Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 493 (1),pp.318-324 2017/11
Papers
Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 486 (2),pp.551-557 2017/04
Papers
GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous Myeloproliferative Neoplasm INTERNAL MEDICINE 56 (4),pp.435-439 2017
Papers
Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 479 (4),pp.808-813 2016/10
Papers
Characterization of gene expression profiling of mouse tissues obtained during the postmortem interval EXPERIMENTAL AND MOLECULAR PATHOLOGY 100 (3),pp.482-492 2016/06
Papers
Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 470 (4),pp.851-856 2016/02
Papers
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - Comprehensive review of 321 original articles Medical Gas Research 5 (1),pp.12 2015/10/19
Papers
Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents MOLECULAR AND CELLULAR BIOCHEMISTRY 403 (1-2),pp.231-241 2015/05
Papers
The involvement of reactive oxygen species derived from NADPH oxidase-1 activation on the constitutive tyrosine auto-phosphorylation of RET proteins FREE RADICAL RESEARCH 48 (4),pp.427-434 2014/04
Papers
UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445 (2),pp.504-510 2014/03
Papers
Detection of a Soluble Form of CD109 in Serum of CD109 Transgenic and Tumor Xenografted Mice PLOS ONE 9 (1),pp.e83385 2014/01
Papers
分子状水素の生体作用―過去6年間で何が明らかとなったか― 安定同位体と生体ガス 医学応用,pp.4-16 2013/11/01
Papers
新規メディカルガスの抗酸化・酸化ストレス耐性作用の分子メカニズム 水素による遺伝子発現変化 日本生理学雑誌,pp.54-54 2013/11
Papers
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833 (5),pp.1006-1016 2013/05
Papers
Molecular hydrogen influences gene expression profiles of rodent organs in healthy and diseased states JOURNAL OF PHYSIOLOGICAL SCIENCES 63,pp.S78-S78 2013
Papers
Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109 AMERICAN JOURNAL OF PATHOLOGY 181 (4),pp.1180-1189 2012/10
Papers
Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of Apc(Min) Mice PLOS ONE 7 (8),pp.e42137 2012/08
Papers
Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7 JOURNAL OF BIOCHEMISTRY 151 (6),pp.599-610 2012/06
Papers
Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats. Medical gas research,pp.15-15 2012/05
Papers
Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes PATHOLOGY INTERNATIONAL 62 (2),pp.99-104 2012/02
Papers
Mimosine-Induced Apoptosis in C6 Glioma Cells Requires the Release of Mitochondria-Derived Reactive Oxygen Species and p38, JNK Activation NEUROCHEMICAL RESEARCH 37 (2),pp.417-427 2012/02
Papers
Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2012,pp.353152 2012
Papers
Sphingosine Kinase 1/S1P Pathway Involvement in the GDNF-Induced GAP43 Transcription JOURNAL OF CELLULAR BIOCHEMISTRY 112 (11),pp.3449-3458 2011/11
Papers
Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 411 (1),pp.143-149 2011/07
Papers
ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI JOURNAL OF NEUROCHEMISTRY 112 (2),pp.511-520 2010/01
Papers
Molecular hydrogen suppresses Fc epsilon RI-mediated signal transduction and prevents degranulation of mast cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 389 (4),pp.651-656 2009/11
Papers
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease NEUROSCIENCE LETTERS 453 (2),pp.81-85 2009/04
Papers
Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis CLINICAL NEUROPATHOLOGY 28 (2),pp.105-112 2009/03
Papers
Recent progress in clinical application of molecular hydrogen 生命健康科学研究所紀要,pp.37-44 2009/03
Papers
Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice. Oncogene,pp.5684-5695 2008/09
Papers
Clinical application of hydrogen gas Annual report of Research Institute of Life and Health Sciences,pp.65-70 2008/03
Papers
A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 366 (1),pp.226-232 2008/02
Papers
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis JOURNAL OF NEUROCHEMISTRY 102 (5),pp.1585-1594 2007/09
Papers
Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities NUCLEIC ACIDS RESEARCH 35 (18),pp.e123 2007/09
Papers
Sprouty2はRETチロシンキナーゼ下流シグナルによる神経芽細胞種の増殖と分化を調節する(Sprouty2 mediates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase) 日本癌学会総会記事 66回,pp.483-483 2007/08
Papers
Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase CANCER SCIENCE 98 (6),pp.815-821 2007/06
Papers
Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase JOURNAL OF CELL SCIENCE 119 (15),pp.3067-3077 2006/08
Papers
Analyses of ultraviolet-induced focus formation of hREV1 protein GENES TO CELLS 11 (3),pp.193-205 2006/03
Papers
RET and neuroendocrine tumors. Pituitary 9 (3),pp.179-92 2006
Papers
CD109 expression in squamous cell carcinoma of the uterine cervix PATHOLOGY INTERNATIONAL 55 (4),pp.165-169 2005/04
Papers
RET tyrosine kinase : the signaling pathway and its role in organogensis Annual report of Research Institute of Life and Health Sciences,pp.25-32 2005/03
Papers
The RET proto-oncogene: A molecular therapeutic target in thyroid cancer CANCER SCIENCE 96 (3),pp.143-148 2005/03
Papers
GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region NUCLEIC ACIDS RESEARCH 33 (13),pp.4191-4201 2005
Papers
Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 323 (1),pp.345-354 2004/10
Papers
Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties CANCER SCIENCE 95 (10),pp.815-821 2004/10
Papers
A targeting mutation of tyrosine 1062 in ret causes a marked decrease of enteric neurons and renal hypoplasia MOLECULAR AND CELLULAR BIOLOGY 24 (18),pp.8026-8036 2004/09
Papers
Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320 (1),pp.108-115 2004/07
Papers
Expression of CD109 in human cancer ONCOGENE 23 (20),pp.3716-3720 2004/04
Papers
RET and neuroendocrine tumors CANCER LETTERS 204 (2),pp.197-211 2004/02
Papers
Identification of a novel GDNF-inducible gene required for renal branching morphogenesis J. Biol. Chem. 278,pp.50386-50392 2003/12
Papers
Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis JOURNAL OF BIOLOGICAL CHEMISTRY 278 (50),pp.50386-50392 2003/12
Papers
Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation CANCER SCIENCE 94 (11),pp.992-997 2003/11
Papers
Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system NEUROSCIENCE 121 (4),pp.899-906 2003
Papers
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation AMERICAN JOURNAL OF PATHOLOGY 161 (1),pp.249-256 2002/07
Papers
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 JOURNAL OF BIOLOGICAL CHEMISTRY 276 (38),pp.35644-35651 2001/09
Papers
Functional analysis of RET with Hirschsprung mutations affecting its kinase domain GASTROENTEROLOGY 121 (1),pp.24-33 2001/07
Papers
Absence of mutations in the granulocyte colony-stimulating factor (G-CSF) receptor gene in patients with myelodysplastic syndrome/acute myeloblastic leukaemia occurring after treatment of aplastic anaemia with G-CSF BRITISH JOURNAL OF HAEMATOLOGY 111 (2),pp.656-658 2000/11
Papers
Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor ONCOGENE 19 (39),pp.4469-4475 2000/09
Papers
A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268 (3),pp.804-808 2000/02
Papers
Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells NEUROSCIENCE 100 (4),pp.841-848 2000
Papers
Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells BRITISH JOURNAL OF HAEMATOLOGY 105 (1),pp.50-57 1999/04
Papers
Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 255 (3),pp.587-590 1999/02
Papers
The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis BRITISH JOURNAL OF HAEMATOLOGY 99 (1),pp.181-189 1997/10
Papers
Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice BLOOD 90 (1),pp.165-173 1997/07
Papers
Cloning and biological activity of murine oncostatin M Leukemia 11 (3),pp.449-450 1997
Papers
Murine oncostatin M only activates the oncostatin M specific high affinity receptor complex which is distinct from the leukemia inhibitory factor receptor complex BLOOD 88 (10),pp.2183-2183 1996/11
Papers
Functional difference of the oncostatin M receptor between human and mouse TISSUE ANTIGENS 48 (4-II),pp.CR208-CR208 1996/10
Papers
Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response BLOOD 87 (9),pp.3655-3668 1996/05
Papers
Mouse oncostatin M: An immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway EMBO JOURNAL 15 (5),pp.1055-1063 1996/03
Papers
MURINE ONCOSTATIN-M TRANSDUCES SIGNALS ONLY THROUGH ITS SPECIFIC RECEPTOR BUT NOT THROUGH THE LIF RECEPTOR GP130 COMPLEX EXPERIMENTAL HEMATOLOGY 23 (8),pp.847-847 1995/08
Papers
INTERLEUKIN-3 (IL-3) POOR-RESPONSIVE INBRED MOUSE STRAINS CARRY THE IDENTICAL DELETION OF A BRANCH POINT IN THE IL-3 RECEPTOR A SUBUNIT GENE BLOOD 85 (9),pp.2331-2336 1995/05
Papers
ONCOGENE-LINKED IN-SITU IMMUNOTHERAPY OF PRE-B LYMPHOMA ARISING IN E-MU/RET TRANSGENIC MICE BRITISH JOURNAL OF CANCER 71 (4),pp.808-813 1995/04
Papers
IMPAIRED INTERLEUKIN-3 (IL-3) RESPONSE OF THE A/J MOUSE IS CAUSED BY A BRANCH POINT DELETION IN THE IL-3 RECEPTOR-ALPHA SUBUNIT GENE EMBO JOURNAL 14 (5),pp.939-950 1995/03
Papers
MULTI-COLONY STIMULATING ACTIVITY OF INTERLEUKIN-5 (IL-5) ON HEMATOPOIETIC PROGENITORS FROM TRANSGENIC MICE THAT EXPRESS IL-5 RECEPTOR EX SUBUNIT CONSTITUTIVELY JOURNAL OF EXPERIMENTAL MEDICINE 181 (3),pp.889-899 1995/03
Papers
DEFECTIVE IL-3 RESPONSE OF A/J MOUSE IS DUE TO ABERRANT SPLICING OF THE IL-3 RECEPTOR-ALPHA MESSENGER-RNA CAUSED BY A BRANCH POINT DELETION BLOOD 84 (10),pp.A510-A510 1994/11
Papers
INTERLEUKIN-5 (IL-5) STIMULATES MUTIPOTENTIAL HEMATOPOIETIC PROGENITORS OF THE TRANSGENIC MOUSE THAT EXPRESSES IL-5 RECEPTOR ALPHA-SUBUNIT CONSTITUTIVELY BLOOD 84 (10),pp.A123-A123 1994/11
Papers
EVIDENCE FOR NONCLONAL HEMATOPOIETIC PROGENITOR-CELL POPULATIONS IN BONE-MARROW OF PATIENTS WITH MYELODYSPLASTIC SYNDROMES BLOOD 84 (2),pp.588-594 1994/07
Papers
GROWTH ANALYSIS OF MARROW CD34-POSITIVE HEMATOPOIETIC PROGENITOR CELLS IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES LEUKEMIA 8 (5),pp.833-838 1994/05
Papers
EFFECTS OF STEM-CELL FACTOR (SCF) ON HUMAN MARROW NEUTROPHIL, NEUTROPHIL MACROPHAGE MIXED, MACROPHAGE AND EOSINOPHIL PROGENITOR-CELL GROWTH INTERNATIONAL JOURNAL OF HEMATOLOGY 59 (2),pp.81-89 1994/02
Papers
THE IL-3 AND GM-CSF RECEPTORS AND SIGNAL-TRANSDUCTION JOURNAL OF CELLULAR BIOCHEMISTRY,pp.3-3 1994/01
Papers
UNIQUE MAST-CELLS THAT LACK THE IL-3 RECEPTOR-ALPHA SUBUNIT BUT RESPOND TO IL-3 BLOOD 82 (10),pp.A364-A364 1993/11
Papers
A case of multiple myeloma with intracerebral metastasis Neurological Surgery,pp.1113-1117 1992
Papers
Genetically modified human bone marrow stromal cells using a retroviral vector carrying the human GM-CSF gene. Progress in clinical and biological research,pp.309-314 1992
Papers
CYTOGENETIC AND CLONAL CULTURE EVALUATION AFTER RESPONSE TO LOW-DOSE ARA-C IN MYELODYSPLASTIC SYNDROMES LEUKEMIA 5 (11),pp.962-966 1991/11
Papers
MODULATION OF THE SECONDARY ANTIBODY-RESPONSE OF MURINE LYMPHOCYTES TO SHEEP RED-BLOOD-CELLS INVITRO BY NEURAMINIDASE AND EXOGLYCOSIDASES IMMUNOLOGY LETTERS 29 (3),pp.235-240 1991/08
Papers
PREFERENTIAL DEVELOPMENT OF PRE-B-LYMPHOMAS WITH DRASTICALLY DOWN-REGULATED N-MYC IN THE E-MU-RET TRANSGENIC MICE EUROPEAN JOURNAL OF IMMUNOLOGY 21 (8),pp.1809-1814 1991/08
Papers
AUGMENTED PRODUCTION OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND ALPHA-BETA-INTERFERON IN MICE INOCULATED WITH HEAT-KILLED CORYNEBACTERIUM-LIQUEFACIENS INFECTION AND IMMUNITY 59 (3),pp.1032-1036 1991/03
Papers
Therapeutic Evaluation of Combination Therapy using C-425 and Antibiotics in Severe Bacterial Infections:A Double Blind Group Comparative Study Kansenshogaku Zasshi,pp.149-161 1990
Papers
Longitudinal Changes in Plasma Insulin and C-peptide Levels in a Case with Disopyramide-induced Hypoglycemia Journal of the Japan Diabetes Society,pp.831-836 (Co-authored) 1989