教員情報 - 市原　正智

イチハラ　マサトシ ICHIHARA Masatoshi
市原　正智

所属生命健康科学部生命医科学科

臨地実習推進部臨床検査技術教育・実習センター

大学院生命健康科学研究科生命医科学専攻

職名教授

著書・論文歴
論文	CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling. Journal of immunology (Baltimore, Md. : 1950) (共著) 2024/02
論文	REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response. Cancer science (共著) 2023/12
論文	Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift Cellular & Molecular Biology Letters 25 (1) (共著) 2020/12
論文	Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors. Cancer letters 489,100-110頁 2020/10/01
論文	Two-week continuous supplementation of hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study MEDICAL GAS RESEARCH 10 (4),163-169頁 2020/10
論文	Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study MEDICAL GAS RESEARCH 10 (3),96-102頁 2020/07
論文	Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. Biochemical and biophysical research communications 525 (4),1074-1080頁 2020/05/14
論文	Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes. Nagoya journal of medical science 82 (2),261-280頁 2020/05
論文	Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993) 41 (4),307-311頁 2019
論文	BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Biochemistry and biophysics reports 15,69-75頁 2018/09
論文	Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles Free Radical Research 52 (4),434-445頁 2018/04/03
論文	Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 493 (1),318-324頁 2017/11
論文	Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 486 (2),551-557頁 2017/04
論文	GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous Myeloproliferative Neoplasm INTERNAL MEDICINE 56 (4),435-439頁 2017
論文	Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 479 (4),808-813頁 2016/10
論文	Characterization of gene expression profiling of mouse tissues obtained during the postmortem interval EXPERIMENTAL AND MOLECULAR PATHOLOGY 100 (3),482-492頁 2016/06
論文	Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 470 (4),851-856頁 2016/02
論文	Beneficial biological effects and the underlying mechanisms of molecular hydrogen - Comprehensive review of 321 original articles Medical Gas Research 5 (1),12 2015/10/19
論文	Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents MOLECULAR AND CELLULAR BIOCHEMISTRY 403 (1-2),231-241頁 2015/05
論文	The involvement of reactive oxygen species derived from NADPH oxidase-1 activation on the constitutive tyrosine auto-phosphorylation of RET proteins FREE RADICAL RESEARCH 48 (4),427-434頁 2014/04
論文	UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445 (2),504-510頁 2014/03
論文	Detection of a Soluble Form of CD109 in Serum of CD109 Transgenic and Tumor Xenografted Mice PLOS ONE 9 (1),e83385 2014/01
論文	分子状水素の生体作用―過去6年間で何が明らかとなったか― 安定同位体と生体ガス医学応用 5 (1),4-16頁 2013/11/01
論文	新規メディカルガスの抗酸化・酸化ストレス耐性作用の分子メカニズム水素による遺伝子発現変化日本生理学雑誌 75 (6),54-54頁 2013/11
論文	Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833 (5),1006-1016頁 2013/05
論文	Molecular hydrogen influences gene expression profiles of rodent organs in healthy and diseased states JOURNAL OF PHYSIOLOGICAL SCIENCES 63,S78-S78頁 2013
論文	Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109 AMERICAN JOURNAL OF PATHOLOGY 181 (4),1180-1189頁 2012/10
論文	Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of Apc(Min) Mice PLOS ONE 7 (8),e42137 2012/08
論文	Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7 JOURNAL OF BIOCHEMISTRY 151 (6),599-610頁 2012/06
論文	Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats. Medical gas research 2 (1),15-15頁 2012/05
論文	Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes PATHOLOGY INTERNATIONAL 62 (2),99-104頁 2012/02
論文	Mimosine-Induced Apoptosis in C6 Glioma Cells Requires the Release of Mitochondria-Derived Reactive Oxygen Species and p38, JNK Activation NEUROCHEMICAL RESEARCH 37 (2),417-427頁 2012/02
論文	Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2012,353152 2012
論文	次世代シークエンスが描く未来とは (Portfolio 医科学の窓) アリーナ = Arena 0 (13),198-209頁 2012
論文	Sphingosine Kinase 1/S1P Pathway Involvement in the GDNF-Induced GAP43 Transcription JOURNAL OF CELLULAR BIOCHEMISTRY 112 (11),3449-3458頁 2011/11
論文	Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 411 (1),143-149頁 2011/07
論文	ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI JOURNAL OF NEUROCHEMISTRY 112 (2),511-520頁 2010/01
論文	Molecular hydrogen suppresses Fc epsilon RI-mediated signal transduction and prevents degranulation of mast cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 389 (4),651-656頁 2009/11
論文	Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease NEUROSCIENCE LETTERS 453 (2),81-85頁 2009/04
論文	Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis CLINICAL NEUROPATHOLOGY 28 (2),105-112頁 2009/03
論文	分子状水素の臨床応用に向けた研究の現状について生命健康科学研究所紀要 5,37-44頁 2009/03
論文	Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice. Oncogene 27 (43),5684-5695頁 2008/09
論文	水素は危険物質か : 水素を用いた新しい抗酸化療法の可能性中部大学生命健康科学研究所紀要 4,65-70頁 2008/03
論文	A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 366 (1),226-232頁 2008/02
論文	RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis JOURNAL OF NEUROCHEMISTRY 102 (5),1585-1594頁 2007/09
論文	Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities NUCLEIC ACIDS RESEARCH 35 (18),e123 2007/09
論文	Sprouty2はRETチロシンキナーゼ下流シグナルによる神経芽細胞種の増殖と分化を調節する(Sprouty2 mediates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase) 日本癌学会総会記事 66回,483-483頁 2007/08
論文	Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase CANCER SCIENCE 98 (6),815-821頁 2007/06
論文	Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase JOURNAL OF CELL SCIENCE 119 (15),3067-3077頁 2006/08
論文	Analyses of ultraviolet-induced focus formation of hREV1 protein GENES TO CELLS 11 (3),193-205頁 2006/03
論文	RET and neuroendocrine tumors. Pituitary 9 (3),179-92頁 2006
論文	CD109 expression in squamous cell carcinoma of the uterine cervix PATHOLOGY INTERNATIONAL 55 (4),165-169頁 2005/04
論文	RETチロシンキナーゼ : シグナル伝達機構と誘導遺伝子の解析中部大学生命健康科学研究所紀要 1,25-32頁 2005/03
論文	The RET proto-oncogene: A molecular therapeutic target in thyroid cancer CANCER SCIENCE 96 (3),143-148頁 2005/03
論文	GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region NUCLEIC ACIDS RESEARCH 33 (13),4191-4201頁 2005
論文	Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 323 (1),345-354頁 2004/10
論文	Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties CANCER SCIENCE 95 (10),815-821頁 2004/10
論文	A targeting mutation of tyrosine 1062 in ret causes a marked decrease of enteric neurons and renal hypoplasia MOLECULAR AND CELLULAR BIOLOGY 24 (18),8026-8036頁 2004/09
論文	Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320 (1),108-115頁 2004/07
論文	Expression of CD109 in human cancer ONCOGENE 23 (20),3716-3720頁 2004/04
論文	RET and neuroendocrine tumors CANCER LETTERS 204 (2),197-211頁 2004/02
論文	Identification of a novel GDNF-inducible gene required for renal branching morphogenesis J. Biol. Chem. 278,50386-50392 2003/12
論文	Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis JOURNAL OF BIOLOGICAL CHEMISTRY 278 (50),50386-50392頁 2003/12
論文	Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation CANCER SCIENCE 94 (11),992-997頁 2003/11
論文	Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system NEUROSCIENCE 121 (4),899-906頁 2003
論文	Sprouty-related protein with EVH-1 domain(Spred)のGDNF/RETシグナル伝達系に及ぼす影響の検討日本癌学会総会記事 61回,264-264頁 2002/10
論文	Characterization of gene expression induced by RET with MEN2A or MEN2B mutation AMERICAN JOURNAL OF PATHOLOGY 161 (1),249-256頁 2002/07
論文	Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 JOURNAL OF BIOLOGICAL CHEMISTRY 276 (38),35644-35651頁 2001/09
論文	Functional analysis of RET with Hirschsprung mutations affecting its kinase domain GASTROENTEROLOGY 121 (1),24-33頁 2001/07
論文	Absence of mutations in the granulocyte colony-stimulating factor (G-CSF) receptor gene in patients with myelodysplastic syndrome/acute myeloblastic leukaemia occurring after treatment of aplastic anaemia with G-CSF BRITISH JOURNAL OF HAEMATOLOGY 111 (2),656-658頁 2000/11
論文	Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor ONCOGENE 19 (39),4469-4475頁 2000/09
論文	A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268 (3),804-808頁 2000/02
論文	Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells NEUROSCIENCE 100 (4),841-848頁 2000
論文	RET遺伝子の機能 (特集遺伝性癌の分子医学--基礎と臨床) 現代医療 31 (9),2323-2329頁 1999/09
論文	Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells BRITISH JOURNAL OF HAEMATOLOGY 105 (1),50-57頁 1999/04
論文	Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 255 (3),587-590頁 1999/02
論文	The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis BRITISH JOURNAL OF HAEMATOLOGY 99 (1),181-189頁 1997/10
論文	Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice BLOOD 90 (1),165-173頁 1997/07
論文	Cloning and biological activity of murine oncostatin M Leukemia 11 (3),449-450頁 1997
論文	Murine oncostatin M only activates the oncostatin M specific high affinity receptor complex which is distinct from the leukemia inhibitory factor receptor complex BLOOD 88 (10),2183-2183頁 1996/11
論文	Functional difference of the oncostatin M receptor between human and mouse TISSUE ANTIGENS 48 (4-II),CR208-CR208頁 1996/10
論文	Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response BLOOD 87 (9),3655-3668頁 1996/05
論文	Mouse oncostatin M: An immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway EMBO JOURNAL 15 (5),1055-1063頁 1996/03
論文	MURINE ONCOSTATIN-M TRANSDUCES SIGNALS ONLY THROUGH ITS SPECIFIC RECEPTOR BUT NOT THROUGH THE LIF RECEPTOR GP130 COMPLEX EXPERIMENTAL HEMATOLOGY 23 (8),847-847頁 1995/08
論文	INTERLEUKIN-3 (IL-3) POOR-RESPONSIVE INBRED MOUSE STRAINS CARRY THE IDENTICAL DELETION OF A BRANCH POINT IN THE IL-3 RECEPTOR A SUBUNIT GENE BLOOD 85 (9),2331-2336頁 1995/05
論文	ONCOGENE-LINKED IN-SITU IMMUNOTHERAPY OF PRE-B LYMPHOMA ARISING IN E-MU/RET TRANSGENIC MICE BRITISH JOURNAL OF CANCER 71 (4),808-813頁 1995/04
論文	IMPAIRED INTERLEUKIN-3 (IL-3) RESPONSE OF THE A/J MOUSE IS CAUSED BY A BRANCH POINT DELETION IN THE IL-3 RECEPTOR-ALPHA SUBUNIT GENE EMBO JOURNAL 14 (5),939-950頁 1995/03
論文	MULTI-COLONY STIMULATING ACTIVITY OF INTERLEUKIN-5 (IL-5) ON HEMATOPOIETIC PROGENITORS FROM TRANSGENIC MICE THAT EXPRESS IL-5 RECEPTOR EX SUBUNIT CONSTITUTIVELY JOURNAL OF EXPERIMENTAL MEDICINE 181 (3),889-899頁 1995/03
論文	DEFECTIVE IL-3 RESPONSE OF A/J MOUSE IS DUE TO ABERRANT SPLICING OF THE IL-3 RECEPTOR-ALPHA MESSENGER-RNA CAUSED BY A BRANCH POINT DELETION BLOOD 84 (10),A510-A510頁 1994/11
論文	INTERLEUKIN-5 (IL-5) STIMULATES MUTIPOTENTIAL HEMATOPOIETIC PROGENITORS OF THE TRANSGENIC MOUSE THAT EXPRESSES IL-5 RECEPTOR ALPHA-SUBUNIT CONSTITUTIVELY BLOOD 84 (10),A123-A123頁 1994/11
論文	EVIDENCE FOR NONCLONAL HEMATOPOIETIC PROGENITOR-CELL POPULATIONS IN BONE-MARROW OF PATIENTS WITH MYELODYSPLASTIC SYNDROMES BLOOD 84 (2),588-594頁 1994/07
論文	GROWTH ANALYSIS OF MARROW CD34-POSITIVE HEMATOPOIETIC PROGENITOR CELLS IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES LEUKEMIA 8 (5),833-838頁 1994/05
論文	EFFECTS OF STEM-CELL FACTOR (SCF) ON HUMAN MARROW NEUTROPHIL, NEUTROPHIL MACROPHAGE MIXED, MACROPHAGE AND EOSINOPHIL PROGENITOR-CELL GROWTH INTERNATIONAL JOURNAL OF HEMATOLOGY 59 (2),81-89頁 1994/02
論文	THE IL-3 AND GM-CSF RECEPTORS AND SIGNAL-TRANSDUCTION JOURNAL OF CELLULAR BIOCHEMISTRY,3-3頁 1994/01
論文	UNIQUE MAST-CELLS THAT LACK THE IL-3 RECEPTOR-ALPHA SUBUNIT BUT RESPOND TO IL-3 BLOOD 82 (10),A364-A364頁 1993/11
論文	A case of multiple myeloma with intracerebral metastasis Neurological Surgery 20 (10),1113-1117頁 1992
論文	Genetically modified human bone marrow stromal cells using a retroviral vector carrying the human GM-CSF gene. Progress in clinical and biological research 377,309-314頁 1992
論文	CYTOGENETIC AND CLONAL CULTURE EVALUATION AFTER RESPONSE TO LOW-DOSE ARA-C IN MYELODYSPLASTIC SYNDROMES LEUKEMIA 5 (11),962-966頁 1991/11
論文	MODULATION OF THE SECONDARY ANTIBODY-RESPONSE OF MURINE LYMPHOCYTES TO SHEEP RED-BLOOD-CELLS INVITRO BY NEURAMINIDASE AND EXOGLYCOSIDASES IMMUNOLOGY LETTERS 29 (3),235-240頁 1991/08
論文	PREFERENTIAL DEVELOPMENT OF PRE-B-LYMPHOMAS WITH DRASTICALLY DOWN-REGULATED N-MYC IN THE E-MU-RET TRANSGENIC MICE EUROPEAN JOURNAL OF IMMUNOLOGY 21 (8),1809-1814頁 1991/08
論文	AUGMENTED PRODUCTION OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND ALPHA-BETA-INTERFERON IN MICE INOCULATED WITH HEAT-KILLED CORYNEBACTERIUM-LIQUEFACIENS INFECTION AND IMMUNITY 59 (3),1032-1036頁 1991/03
論文	重症細菌感染症に対する静注用人免疫グロブリン (C-425) と抗生剤との併用療法についての臨床評価:二重盲検法による比較試験感染症学雑誌 64 (2),149-161頁 1990
論文	経過中血しょうインスリン，Ｃ‐ペプチドの上昇が観察されたｄｉｓｏｐｙｒａｍｉｄｅ低血糖の１例糖尿病 32 (11),831-836頁 (共著) 1989