教員情報 - 山下　均

ヤマシタ　ヒトシ YAMASHITA Hitoshi
山下　均

所属生命健康科学部生命医科学科

大学院生命健康科学研究科生命医科学専攻

臨地実習推進部臨床検査技術教育・実習センター

大学院生命健康科学研究科生命健康科学研究所

職名教授

著書・論文歴
著書	エネルギー代謝モデル動物実験ガイド老化・老年病研究のための動物実験ガイドブック,52-57頁 (共著) 2008/05
著書	脂肪組織の代謝—7.ミトコンドリア:UCP1, PGC1ファミリーなど糖尿病カレントライブラリー7「脂肪細胞と脂肪組織」,117-122頁 (共著) 2007/04
著書	A novel model for the study of angiogenesis. Skeletal Muscle Research. Part 1. Cellular Physiology & Biochemistry,55-67頁 (共著) 1993
著書	Is there an intimate interplay between temperature acclimation and exogenous insulin ? --with special reference to the participation of brown adipose tissue--. Medicine and sport science 37,237-242頁 (共著) 1992
論文	The effect of Dunaliella tertiolecta supplementation on diet-induced obesity in UCP1-deficient mice. Bioscience, biotechnology, and biochemistry 88 (1),16-25頁 (共著) 2024/01
論文	CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells. Biochem. Biophys. Res. Commun. 641,162-167頁 (共著) 2023
論文	Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies. Int. J. Mol. Sci. 24 (3),2741 (共著) 2023
論文	CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice. J Biochem. 171 (1),63-73頁 (共著) 2022
論文	CREG1 improves diet-induced obesity via uncoupling protein 1-dependent manner in mice. Genes to Cells 27,202-213頁 (共著) 2022
論文	Sustained high body temperature exacerbates cognitive function and Alzheimer's disease-related pathologies. Scientific Reports 12,12273 (共著) 2022
論文	脂肪細胞をターゲットとした肥満・メタボの予防. Food STYLE 21. Vol 26 (5),49-51頁 (単著) 2022
論文	Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice. Int. J. Mol. Sci. 22 (3),1276 (共著) 2021
論文	Brown adipocytes suppress kidney stone formation via heat-producing protein, uncoupling protein 1. J Urol. Stone disease: Basic research and Pathophysiology 203 (4S),e81-e82頁 (共著) 2020
論文	Dietary Supplementation with Dunaliella Tertiolecta Prevents Whitening of Brown Fat and Controls Diet-Induced Obesity at Thermoneutrality in Mice. Nutrients 12 (6),1686 (共著) 2020
論文	High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90. J Biol Chem. 295 (52),18010-18022頁 (共著) 2020
論文	Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. BBA Molecular Basis of Disease. 1866 (7),165762 (共著) 2020
論文	脂肪組織特異的CREG1-Tgマウスを利用した老化研究細胞 52 (11),41-45頁 (共著) 2020
論文	Brown adipocytes and β3-stimulant-induced brown-like adipocytes contribute to the prevention of renal crystal formation. Am J Physiol Renal Physiol. 2019 Jun 1 316 (6),F1282-F1292頁 (共著) 2019
論文	CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro. J Biochem. Jan 1;165 (1),47-55頁 (共著) 2019
論文	CREG1 stimulates brown adipocyte formation and ameliorates diet-induced obesity in mice. FASEB J. 33 (7),8069-8082頁 (共著) 2019
論文	Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease. FEBS open bio 7 (7),1009-1016 (共著) 2017/07
論文	脂肪組織特異的CREG1トランスジェニックマウスを利用した褐色脂肪化促進と生活習慣病改善の検討基礎老化研究 40 (3),35-38頁 (共著) 2016
論文	Asp3Gly polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization. FEBS Lett. 589,2382-2387頁 (共著) 2015
論文	Dietary supplementation with evodiamine prevents obesity and improves insulin resistance in ageing mice. J. Funct. Foods 19,320-329頁 (共著) 2015
論文	A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction. Scientific reports 4,4517 (共著) 2014/03
論文	A natural compound Evo(kes) signaling for fat regulation. Cell Cycle Vol.13 (単著) 2014
論文	Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. PLoS ONE Vol.8 (共著) 2013
論文	エボジアミンは肥満とインスリン抵抗性を改善する基礎老化研究 37 (1),21-23頁 (共著) 2013
論文	Mimosine-induced apoptosis in C6 glioma cells requires the release of mitochondria-derived reactive oxygen species and p38, JNK activation. Neurochemical research 37 (2),417-27 (共著) 2012/02
論文	Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice. PloS one 7 (6),e39807 (共著) 2012
論文	TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J. Appl. Physiol. Vol.112,1223-1232頁 (共著) 2012
論文	褐色脂肪組織とメタボリックシンドローム肥満研究 18 (3),154-155頁 (共著) 2012
論文	β₃-Adrenergic activation of sequential Ca(2+) release from mitochondria and the endoplasmic reticulum and the subsequent Ca(2+) entry in rodent brown adipocytes. Cell calcium 49 (6),400-414頁 (共著) 2011/06
論文	Fatty acid-binding protein 3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells. Genes to Cells Vol.16 (共著) 2011
論文	Evodiamine inhibits adipogenesis via EGFR-PKCα-ERK signaling pathway. FEBS Lett. Vol.583 (共著) 2009
論文	Impaired basal thermal homeostasis in rats lacking capsaicin-sensitive peripheral small sensory neurons. Journal of biochemistry 143 (3),385-393頁 (共著) 2008/03
論文	Evodiamine improves diet-induced obesity in a UCP1-independent manner: Involvement of anti-adipogenic mechanism and ERK/MAPK signaling. Endocrinol. Vol.149 (共著) 2008
論文	Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents. Biochem. Biophys. Res. Commun. Vol.377 (共著) 2008
論文	Uncoupling protein 1 contributes to fat-reducing effect of leptin. Obesity research & clinical practice 1,233-241頁 (共著) 2007/12
論文	Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. American journal of physiology. Endocrinology and metabolism 290 (5),E1014-E1021頁 (共著) 2006/05
論文	Indispensable role of mitochondrial uncoupling protein 1 (UCP1) for anti-obesity effect of b3-adrenergic stimulation. Am. J. Physiol. Vol.290 (共著) 2006
論文	Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice. Pfluger Arch.-Eur. J. Physiol. Vol.452 (共著) 2006
論文	Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes 54 (5),1385-1391頁 (共著) 2005/05
論文	Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1). Journal of molecular histology 36 (1-2),35-44 (共著) 2005/02
論文	UCP1 deficiency increases susceptibility to diet-induced obesity with age. Aging Cell Vol.4,147-155頁 (共著) 2005
論文	Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes Vol.54 (共著) 2005
論文	老化と熱産生機能低下日本医事新報 Vol.4255,30-32頁 (単著) 2005
論文	エネルギー応答、ストレス応答から老化制御へ日本老年医学会雑誌 40 (6),578-581頁 (共著) 2003/11
論文	Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscles during energy deprivation. Biochem. J. Vol.375 (共著) 2003
論文	Muscle type difference in the regulation of UCP3 under cold conditions. Biochem. Biophys. Res. Commun. Vol.305 (共著) 2003
論文	Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microscopy research and technique 59 (4),331-334頁 (共著) 2002/11
論文	Effect of age on the gene expression of neural-restrictive silencing factor NRSF/REST. Neurobiology of aging 23 (2),255-262頁 (共著) 2002
論文	Effects of aging and denervation on the expression of uncoupling proteins in slow- and fast-twitch muscles of rats. J. Biochem. (共著) 2002
論文	加齢にともなう肥満の進展とUCP1の役割肥満研究 8,131-135頁 (共著) 2002
論文	老化研究のための実験動物使用ガイドブックーげっ歯類ー,88-98頁 (共著) 2002
論文	加齢に伴う肥満の進展とミトコンドリア脱共役蛋白質の役割公益信託加藤記念難病研究助成研究報告集 13,41-48頁 (単著) 2001
論文	Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Biochem. Biophys. Res. Commun. (共著) 2000
論文	Differences in induction of uncoupling protein genes in adipose tissues between young and old rats during cold exposure. FEBS Lett. (共著) 1999
論文	Emergence of brown adipocytes in white fat in mice is under genetic control. : Effects on body weight and adiposity. J. Clin. Invest. (共著) 1998
論文	Mice lacking mitochondrial uncoupling protein are cold sensitive but not obese. Nature (共著) 1997
論文	UCP遺伝子の調節によって肥満は抑制できるのか？実験医学 15,1850-1852頁 (単著) 1997
論文	Uncoupling protein 1 Molecular Medicine ノックアウトマウスデータブック 34,512 (共著) 1997
論文	A single bout of exercise brings about capillary growth in skeletal muscle through basic fibroblast growth factor (bFGF). Pathophysiology 3 (共著) 1996
論文	Responses of brown-adipose-tissue activity in the rat to 14 days of spaceflight. Pathophysiology 3 (共著) 1996
論文	褐色脂肪組織特異的脱共役蛋白質の発現制御上原記念生命科学財団研究報告集 10,92-93頁 (単著) 1996
論文	Acute or chronic exercise alters angiotensin II-induced contraction of rat aorta. Jpn. J. Physiol. 45 (共著) 1995
論文	Alterations of superoxide dismutase iso-enzyme activity, content, and mRNA expression with aging in rat skeletal muscle. Mech. Ageing Dev. 84 (共著) 1995
論文	Changes in immunoreactive manganese-superoxide dismutase content in rat tissues under heat or cold environment. Pathophysiology 2 (共著) 1995
論文	Effects of hypobaric hypoxia on antioxidant enzymes in rats. J. Physiol. (Lond.) 489 (共著) 1995
論文	Effects of swimming training on the lysosomal enzyme system in brown adipose tissue of rats: an analogy between swimming exercise and cold acclimation. Acta. Physiol. Scand. 155 (共著) 1995
論文	Immunomodulation by cells of mononuclear phagocyte lineage in acute cold-stressed or cold-acclimated mice. Immunology 86 (共著) 1995
論文	Increased growth of brown adipose tissue but its reduced thermogenic activity in creatine-depleted rats fed β-guanidinopropionic acid. Biochim. Biophys. Acta 1230 (共著) 1995
論文	Insulin stimulates the expression of basic fibroblast growth factor in rat brown adipocyte primary culture. Eur. J. Cell Biol. 68 (共著) 1995
論文	Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture. Cell Growth Differ. 6 (共著) 1995
論文	Responses of brown adipose tissue activity to unloading in rats. J. Appl. Physiol. 78 (共著) 1995
論文	環境変化と褐色脂肪組織--unloadingの影響-- 運動生化学 7,103-105頁 (共著) 1995
論文	運動と血管新生中富健康科学振興財団第5回研究助成業績集,26-30頁 (共著) 1995
論文	A novel angiogenesis model using interstitial cells derived from skeletal muscle. Comp. Biochem. Physiol. 109A (共著) 1994
論文	Basic fibroblast growth factor contributes to the enlargement of brown adipose tissue during cold acclimation. Pflugers Arch. 428 (共著) 1994
論文	Chronic exposure to simulated altitude does not increase angiogenic activity in skeletal muscle of rats. Tohoku J. Exp. Med. 172 (共著) 1994
論文	Discordance between thermogenic activity and expression of uncoupling protein in brown adipose tissue of old rats. J. Gerontol. 49 (共著) 1994
論文	Is heat acclimation able to increase whole-body sensitivity to insulin ? Res. Commun. Chem. Pathol. Pharmacol. 84 (共著) 1994
論文	Is insulin-like growth factor I involved in brown adipose tissue enlargement ? Life Sci. 55 (共著) 1994
論文	Prevention of ongoing lipid peroxidation by wound excision and superoxide dismutase treatment in the burned rat. Am. J. Emerg. Med. 12 (共著) 1994
論文	The effect of an SOD derivative (SM-SOD) administration in a burned rat model. Tohoku J. Exp. Med. 174 (共著) 1994
論文	Changes in immunoreactive manganese-superoxide dismutase concentration in human serum after 93-h strenuous physical exercise. Clin. Chim. Acta. 215 (共著) 1993
論文	Effect of endurance training on angiogenic activity in skeletal muscle. Pflugers Arch. 422 (共著) 1993
論文	Effect of physical exercise on urinary excretion of CuZn-superoxide dismutase in male high school students. Acta. Physiol. Scand. 148 (共著) 1993
論文	Effect of running training on uncoupling protein mRNA expression in rat brown adipose tissue. Int. J. Biometeorol. 37 (共著) 1993
論文	Superoxide dismutase with prolonged in vivo half-life inhibits intravascular hemolysis and renal injury in burned rats. Am. J. Emerg. Med. 11 (共著) 1993
論文	運動と血管新生運動生化学 5,90-95頁 (共著) 1993
論文	Effects of brief physical exercise on the concentrations of immunoreactive superoxide dismutase isoenzymes in human plasma. Tohoku J. Exp. Med. 167 (共著) 1992
論文	Insulin administration induces capillary growth in brown adipose tissue of heat-exposed rats. Comp. Biochem. Physiol. 103A (共著) 1992
論文	Interaction between heat acclimation and exogenous insulin in brown adipose tissue of rats. Int. J. Biometeorol. 36 (共著) 1992
論文	Training effects on concentrations of immunoreactive superoxide dismutase isoenzymes in human plasma. Acta. Physiol. Scand. 146 (共著) 1992
論文	褐色脂肪細胞の増殖と血管新生における寒冷馴化ラット血漿の効果日本生気象学会雑誌 29,113-118頁 (共著) 1992
論文	Serum manganese-superoxide dismutase in patients with neuromuscular disorders as judged by an ELISA. Res. Commun. Chem. Pathol. Pharmacol. 72 (共著) 1991
論文	Proteose peptone enhances production of tissue-type plasminogen activator from human diploid fibroblasts. Biochem. Biophys. Res. Commun. 150 (共著) 1988
論文	Microbial production of plant gibberellins and related compounds from ent-kaurene derivatives in Gibberella fujikuroi. Agric. Biol. Chem. 45 (共著) 1981
論文	Synthesis and microbial transformation of ent-12.BETA.-hydroxykaur-16-ene. 44 (9),2249-2250頁 (共著) 1980