Faculty - KAWAMOTO Yoshiyuki |

KAWAMOTO Yoshiyuki

Department / Course College of Life and Health Sciences Department of Biomedical Sciences

Office for the Coordination of Clinical Practicums Center for Clinical Examination Practicum Support

Graduate School of Life and Health Sciences Department of Biomedical Sciences

Global and Community Affairs Center for Community Affairs

Job Associate Professor

Book and thesis
Papers	LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration Cancers,pp.2781-2781 2023/05/16
Papers	Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case-control study. Archives of toxicology 96 (10),pp.2785-2797 2022/10
Papers	Analysis of the inhibitory effect of white adipose differentiation by synthetic melanin and squid ink. 日本農芸化学会大会講演要旨集(Web) 2022
Papers	CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. Cancer science 112 (7),pp.2770-2780 2021/07
Papers	Analysis of molecular mechanism of cell proliferation inhibition by synthetic melanin 日本分子生物学会年会プログラム・要旨集(Web) 2021
Papers	Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. Biochemical and biophysical research communications 525 (4),pp.1074-1080 2020/05/14
Papers	Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes. Nagoya journal of medical science 82 (2),pp.261-280 2020/05
Papers	Oxidized Perilla and Linseed Oils Induce Neuronal Apoptosis by Caspase-Dependent and -Independent Pathways Foods,pp.538-538 2020/04/26
Papers	Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action. American journal of cancer research 10 (1),pp.336-349 2020
Papers	メラニンによる癌細胞増殖抑制と機序の解析(Analysis of cancer cell growth suppression and mechanism by melanin) 日本癌学会総会記事 78回,pp.E-3038 2019/09
Papers	メラニンによる癌細胞増殖抑制と機序の解析(Analysis of cancer cell growth suppression and mechanism by melanin) 日本癌学会総会記事 78回,pp.E-3038 2019/09
Papers	Inhibition of mast cell degranulation by melanin. Biochemical pharmacology 163,pp.178-193 2019/05
Papers	システインを介したRETキナーゼの活性阻害日本衛生学雑誌,pp.S175-S175 2019/02
Papers	水溶解メラニンによるマスト細胞の活性化抑制日本衛生学雑誌,pp.S171-S171 2019/02
Papers	Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury. Circulation research 123 (12),pp.1326-1338 2018/12/07
Papers	Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury. Circulation Research 123 (12),pp.1326-1338 2018/12
Papers	BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Biochemistry and biophysics reports 15,pp.69-75 2018/09
Papers	合成メラニンによるがん細胞増殖および遊走の抑制日本生化学会大会プログラム・講演要旨集,pp.[3P-275] 2018/09
Papers	栄養・食品機能と老化、疾患予防可食性ポリマーによる疾病予防の可能性中部大学生命健康科学研究所紀要,pp.97-97 2018/03
Papers	Cell growth inhibition by solubilized eumelanin CANCER SCIENCE,pp.778 2018/01
Papers	BCL2とJNK経路はPh1陽性ALLの良い治療標的となる生命科学系学会合同年次大会,pp.[1P-1022] 2017/12
Papers	低酸素環境におけるRET変異体の機能解析生命科学系学会合同年次大会,pp.[1P-0600] 2017/12
Papers	合成メラニンによるマスト細胞の活性化抑制生命科学系学会合同年次大会,pp.[1P-1080] 2017/12
Papers	可溶化ユーメラニンによる細胞増殖抑制日本癌学会総会記事 76回,pp.P-2410 2017/09
Papers	Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR. Biochemical and biophysical research communications 486 (2),pp.551-557 2017/04/29
Papers	Morphological analyses in fragility of pili torti with Björnstad syndrome. The Journal of dermatology 44 (4),pp.455-458 2017/04
Papers	アレルギー2 RETトランスジェニックマウスにおける接触過敏症の解析(Allergy(2) Analysis of contact hypersensitivity in RET-transgenic mice) 日本免疫学会総会・学術集会記録 45 (Proceedings),pp.168-168 2016/11
Papers	Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. Biochemical and biophysical research communications 479 (4),pp.808-813 2016/10/28
Papers	6-ジンゲロールによるT細胞活性化抑制機序に基づくショウガのアレルギー性鼻炎予防効果日本生化学会大会プログラム・講演要旨集 89回,pp.[1P-342] 2016/09
Papers	Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells. Biochemical and biophysical research communications 470 (4),pp.851-6 2016/02/19
Papers	Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. The Journal of nutritional biochemistry 27,pp.112-22 2016/01
Papers	メラノーマ自然発症および移植モデルマウスを用いたIL-9の抗腫瘍効果の解析日本生化学会大会・日本分子生物学会年会合同大会講演要旨集,pp.[3P1122]-[3P1122] 2015/12
Papers	Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor. Journal of cellular biochemistry 116 (10),pp.2227-38 2015/10
Papers	Commentary to Pastore et al. (2014): epidermal growth factor receptor signaling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors. Archives of toxicology 88 (12),pp.2319-20 2014/12
Papers	Epigenetic alterations of histone methylation in human melanoma development GENES & GENETIC SYSTEMS 89 (6),pp.316-316 2014/12
Papers	メラノーマモデルマウスを用いたIL-9の抗腫瘍効果の解析日本生化学会大会プログラム・講演要旨集,pp.[3P-426] 2014/10
Papers	Isolation of a hemidesmosome-rich fraction from a human squamous cell carcinoma cell line. Experimental cell research 324 (2),pp.172-82 2014/06/10
Papers	A case of Björnstad syndrome caused by novel compound heterozygous mutations in the BCS1L gene. The British journal of dermatology,pp.970-973 2014/04
Papers	Actin-binding protein, Espin: a novel metastatic regulator for melanoma. Molecular cancer research : MCR 12 (3),pp.440-6 2014/03
Papers	T細胞受容体刺激による細胞内ROS産生の二相性と機序解析日本生化学会大会プログラム・講演要旨集,pp.3P-188 2013/09
Papers	卵白アルブミン誘導性鼻アレルギーモデルに対するショウガの抗アレルギー作用(Antiallergic effect of ginger on ovalbumin-induced nasal allergy model) 日本生化学会大会プログラム・講演要旨集,pp.1P-443 2013/09
Papers	RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy. Dermatology research and practice 2012,pp.354191-354191 2012
Papers	T細胞シグナル伝達クルクミンによるT細胞のアクチン再構成と脂質ラフトを介するシグナル伝達の抑制(Inhibition of lipid raft-mediated signaling and actin reorganization by curcumin in T cells) 日本免疫学会総会・学術集会記録 40,pp.209-209 2011/11
Papers	Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury. Neurobiology of disease 43 (3),pp.706-14 2011/09
Papers	メラノーマ自然発症RETトランスジェニックマウスを用いた腫瘍関連バイオマーカーの探索日本生化学会大会プログラム・講演要旨集,pp.2P-0573 2011/09
Papers	Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells. Molecular biology of the cell 22 (6),pp.736-47 2011/03/15
Papers	マンガン曝露によって誘導される細胞死へのRETタンパク質の関与日本衛生学雑誌,pp.464-464 2011/02
Papers	Control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions. Enzyme research 2011,pp.896567-896567 2011
Papers	Molecular Network Associated with MITF in Skin Melanoma Development and Progression. Journal of skin cancer 2011,pp.730170-730170 2011
Papers	A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. Journal of cellular biochemistry 110 (2),pp.399-407 2010/05/15
Papers	老化の生化学ヒ素による脂質ラフトを介する活性酸素種産生機序基礎老化研究,pp.39-39 2010/05
Papers	1,4-butanediyl-bismethanethiosulfonate (BMTS) induces apoptosis through reactive oxygen species-mediated mechanism. Journal of cellular biochemistry 108 (5),pp.1059-65 2009/12/01
Papers	1,4-butanediyl-bismethanethiosulfonate (BMTS) induces reactive oxygen species-mediated apoptotic signals independent of stress-activated MAPK cascade in Jurkat cells. J Cell Biochem 108 (5),pp.1059-65 2009/12/01
Papers	Bid truncation mediated by caspases-3 and-9 in vinorelbine-induced apoptosis APOPTOSIS 13 (4),pp.523-530 2008/04
Papers	環境が原因でおこる病気中部大学生命健康科学研究所紀要,pp.29-33 2008/03
Papers	Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development JOURNAL OF INVESTIGATIVE DERMATOLOGY 127 (5),pp.1244-1249 2007/05
Papers	ヒ素の科学とよもやま話中部大学生命健康科学研究所紀要,pp.29-33 2007/03
Papers	天然物を用いた新しい免疫制御機構の解析日本衛生学雑誌,pp.704-704 2007/03
Papers	[Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation]. Nihon eiseigaku zasshi. Japanese journal of hygiene,pp.3-8 2007/01
Papers	紫外線がRETチロシンキナーゼの活性制御を介して悪性黒色腫を誘導する機構日本衛生学雑誌,pp.3-8 2007/01
Papers	【メラノーマ】悪性黒色腫の発症機構の解析細胞,pp.573-577 2006/12
Papers	Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles JOURNAL OF INVESTIGATIVE DERMATOLOGY 126 (11),pp.2547-2550 2006/11
Papers	環境有害物質がシグナル伝達分子の機能修飾を介して疾患を誘発する機構一酸化窒素による別経路でのチロシンキナーゼの活性化日本衛生学雑誌,pp.215-215 2006/03
Papers	細胞膜脂質ラフトを介する活性酸素種産生機序の解析生活習慣病予防をめざして中部大学生命健康科学研究所紀要,pp.1-6 2006/03
Papers	A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities FEBS LETTERS 580 (3),pp.839-843 2006/02
Papers	【癌の漢方療法新しい展開】十全大補湯による腫瘍特異的細胞傷害性T細胞の誘導 Biotherapy,pp.33-39 2006/01
Papers	Cutting edge: CD8(+)CD122(+) regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8(+) T cells JOURNAL OF IMMUNOLOGY 175 (11),pp.7093-7097 2005/12
Papers	T細胞受容体刺激による細胞内活性酸素種の産生機序日本免疫学会総会・学術集会記録,pp.220-220 2005/11
Papers	亜砒酸ナトリウムにより誘導される膜脂質ラフトを介するROS産生(Analysis of membrane lipid raft-mediated ROS production induced by sodium arsenite) 日本免疫学会総会・学術集会記録 35,pp.220-220 2005/11
Papers	メラノーマ自然発症RETトランスジェニックマウスに対するクルクミン代謝産物含有食の延命効果の検討日本癌学会総会記事,pp.216-216 2005/09
Papers	Mechanisms of redox-linked regulation of membrane-associated protein tyrosine kinases activation. Annual report of Research Institute of Life and Health Sciences,pp.17-24 2005/03
Papers	Redox control of catalytic activities of membrane-associated protein tyrosine kinases ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 434 (1),pp.3-10 2005/02
Papers	Essential roles of CD8(+)CD122(+) regulatory T cells in the maintenance of T cell homeostasis JOURNAL OF EXPERIMENTAL MEDICINE 200 (9),pp.1123-1134 2004/11
Papers	ヒ素刺激によるT細胞の活性酸素種産生に関わるラフト局在性タンパク質の解析日本免疫学会総会・学術集会記録,pp.322-322 2004/11
Papers	制御性T細胞免疫恒常性維持におけるCD8+CD122+制御性T細胞の不可欠な役割(Regulatory T cells: Essential roles of CD8+CD122+ regulatory T cells in the maintenance of immune homeostasis) 日本免疫学会総会・学術集会記録 34,pp.11-11 2004/11
Papers	質量分析によるRET受容体型チロシンキナーゼの自己リン酸化部位の同定日本癌学会総会記事,pp.315-315 2004/09
Papers	【活性酸素と免疫】活性酸素と免疫細胞のアポトーシスアレルギー科,pp.135-141 2004/08
Papers	Inhibition of Fas-mediated apoptotic cell death of murine T lymphocytes in a mouse model of immunosenescence in linkage to deterioration in cell membrane raft function IMMUNOLOGY 112 (1),pp.64-71 2004/05
Papers	腫瘍免疫と漢方メラノーマ自然発症モデルにおける漢方のがん抑制効果産婦人科漢方研究のあゆみ,pp.23-29 2004/05
Papers	Identification of RET autophosphorylation sites by mass spectrometry JOURNAL OF BIOLOGICAL CHEMISTRY 279 (14),pp.14213-14224 2004/04
Papers	c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model CANCER RESEARCH 64 (3),pp.801-806 2004/02
Papers	c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model CANCER RESEARCH 64 (3),pp.801-806 2004/02
Papers	Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12),(14)-prostaglandin J(2) MOLECULAR AND CELLULAR BIOLOGY 24 (1),pp.36-45 2004/01
Papers	Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12),(14)-prostaglandin J(2) MOLECULAR AND CELLULAR BIOLOGY 24 (1),pp.36-45 2004/01
Papers	T細胞の膜脂質ラフトを介した酸化ストレスの惹起におけるアクチンの関与日本免疫学会総会・学術集会記録,pp.104-104 2003/11
Papers	チロシンキナーゼの活性化における高度に保存されたシステインの役割日本免疫学会総会・学術集会記録,pp.38-38 2003/11
Papers	Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal CELL DEATH AND DIFFERENTIATION 10 (7),pp.772-781 2003/07
Papers	Transgenic mouse models for immunosenescence Current Genomics 4 (5),pp.435-443 2003/07
Papers	Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation FREE RADICAL BIOLOGY AND MEDICINE 34 (5),pp.598-606 2003/03
Papers	Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation FREE RADICAL BIOLOGY AND MEDICINE 34 (5),pp.598-606 2003/03
Papers	Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation FREE RADICAL BIOLOGY AND MEDICINE 34 (5),pp.598-606 2003/03
Papers	リンパ球におけるPKCαの高発現による細胞膜を介する外的シグナル伝達の低下とアポトーシス抑制における免疫老化の検討日本薬学会年会要旨集,pp.166-166 2003/03
Papers	4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions Molecular Aspects of Medicine 24 (4-5),pp.231-238 2003
Papers	4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions Molecular Aspects of Medicine 24 (4-5),pp.231-238 2003
Papers	Paeoniflorinのリンパ球に対するapoptosis誘導活性の検出と機序の解析日本免疫学会総会・学術集会記録,pp.86-86 2002/10
Papers	T細胞における酸化ストレスによるp38MAPキナーゼ情報伝達経路の活性化と細胞膜脂質ラフトの関与日本免疫学会総会・学術集会記録,pp.77-77 2002/10
Papers	チロシンキナーゼの活性化の機序における分子内に保存されたシステインの役割日本免疫学会総会・学術集会記録,pp.184-184 2002/10
Papers	Redox-linked signal transduction pathways for protein tyrosine kinase activation ANTIOXIDANTS & REDOX SIGNALING 4 (3),pp.517-531 2002/06
Papers	Redox-linked signal transduction pathways for protein tyrosine kinase activation ANTIOXIDANTS & REDOX SIGNALING 4 (3),pp.517-531 2002/06
Papers	メラノーマ自然発症トランスジェニックマウス系における十全大補湯の抗腫瘍効果腫瘍特異的細胞傷害性T細胞免疫の誘導を介する作用漢方医学,pp.65-68 2002/05
Papers	Activation of caspase-8 is critical for sensitivity to cytotoxic anti-Fas anti body-induced apoptosis in human ovarian cancer cells APOPTOSIS 7 (2),pp.107-113 2002/04
Papers	Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine CANCER RESEARCH 62 (8),pp.2414-2422 2002/04
Papers	Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine CANCER RESEARCH 62 (8),pp.2414-2422 2002/04
Papers	A conserved cysteine residue in the catalytic domain plays a key role in activation of protein tyrosine kinase RET FREE RADICAL BIOLOGY AND MEDICINE 33,pp.S88-S88 2002
Papers	The highly conserved MXXCW motif initially switches on protein tyrosine kinase activity XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL,pp.229-234 2002
Papers	1,4-Butanediyl-bis methanethiosulfonate(BMTS)は膜ラフトの凝集及びROS(reactive oxygen species)産生を伴うネズミTリンパ球のアポトーシスを誘発する(1,4-butanediyl-bis methanethiosulfonate (BMTS) induced apoptosis of murine T lymphocytes accompanying aggregation of membrane rafts and ROS production) 日本免疫学会総会・学術集会記録 31,pp.84-84 2001/12
Papers	PKCαトランスジェニックマウスにおけるリンパ球のPKCα高発現とアポトーシス抑制について日本免疫学会総会・学術集会記録,pp.191-191 2001/12
Papers	RET-トランスジェニックマウスに一次発生する悪性メラノーマに特異的な細胞傷害性Tリンパ球免疫の誘導日本免疫学会総会・学術集会記録,pp.177-177 2001/12
Papers	亜ヒ酸塩は膜ラフト依存方法においてレドックスリンクAkt経路の引金となる(Arsenite Triggers a Redox-Linked Akt Pathway in a Membrane Raft-Dependent Way) 日本免疫学会総会・学術集会記録 31,pp.84-84 2001/12
Papers	培養肝癌細胞における抗癌剤併用によるグリチルリチン(GL)のアポトーシス増強効果日本免疫学会総会・学術集会記録,pp.87-87 2001/12
Papers	細胞膜脂質ラフトにおける酸化ストレスによるチロシンキナーゼの活性化と機序日本免疫学会総会・学術集会記録,pp.189-189 2001/12
Papers	RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis ONCOGENE 20 (51),pp.7536-7541 2001/11
Papers	T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice JOURNAL OF INVESTIGATIVE DERMATOLOGY 117 (3),pp.694-701 2001/09
Papers	T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice JOURNAL OF INVESTIGATIVE DERMATOLOGY 117 (3),pp.694-701 2001/09
Papers	Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells FREE RADICAL BIOLOGY AND MEDICINE 31 (1),pp.20-30 2001/07
Papers	4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response Biochemical and Biophysical Research Communications 282 (2),pp.557-561 2001
Papers	N-methyl-N-nitro-N-nitrosoguanidinによるT細胞アポトーシス誘導のメカニズムの検討日本免疫学会総会・学術集会記録,pp.270-270 2000/11
Papers	抗c-Kit抗体によるメラノーマの発症抑制日本免疫学会総会・学術集会記録,pp.165-165 2000/11
Papers	浸透圧ストレスによるRETキナーゼ活性化には細胞内のジスルフィド結合による二量体形成が関与する日本免疫学会総会・学術集会記録,pp.146-146 2000/11
Papers	4-hydroxy-2-nonenal, the end product of lipid peroxidation, is a specific inducer of cyclooxygenase-2 gene expression BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273 (2),pp.437-441 2000/07
Papers	Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes - 15-deoxy-Delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases JOURNAL OF BIOLOGICAL CHEMISTRY 275 (15),pp.11291-11299 2000/04
Papers	Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: Correlation of enzyme induction with the formation of reactive oxygen intermediates CANCER RESEARCH 60 (2),pp.219-225 2000/01
Papers	Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation Antioxidants and Redox Signaling 2 (4),pp.841-849 2000
Papers	抗腫瘍性プロスタグランジン類による遺伝子発現誘導生化学,pp.882-882 1999/08