Faculty - ICHIHARA Masatoshi |

（Last updated : 2025-08-20 16:59:57）

ICHIHARA Masatoshi

Department / Course

College of Life and Health Sciences Department of Biomedical Sciences

Office for the Coordination of Clinical Practicums Center for Clinical Examination Practicum Support

Graduate School of Life and Health Sciences Department of Biomedical Sciences

Job Professor

Belonging society
	THE JAPANESE SOCIETY OF INTERNAL MEDICINE
	THE JAPANESE SOCIETY OF HEMATOLOGY
	THE JAPANESE SOCIETY OF PATHOLOGY
	THE JAPANESE CANCER ASSOCIATION
	THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Present specialized field
Human pathology, Cell biology, Hematology and medical oncology, Molecular biology, Experimental pathology

Book and thesis
Papers	REV7 subunit of mutagenic DNA polymerase ζ as a predictive biomarker for the efficacy of immune checkpoint inhibitor therapy in melanoma Journal of clinical pathology 78 (8),pp.573-577 (Co-authored) 2025/06/05
Papers	CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling. Journal of immunology (Baltimore, Md. : 1950) (Co-authored) 2024/02
Papers	REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response. Cancer science (Co-authored) 2023/12
Papers	Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift Cellular & Molecular Biology Letters (Co-authored) 2020/12
Papers	Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors. Cancer letters 489,pp.100-110 2020/10/01
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Academic conference presentation
2017/10	Molecular hydrogen activates the mitochondrial unfolded protein response via epigenetic histone modification and ameliorates ultraviolet light-induced damage in Caenorhabditis elegans (8th World Congress on Targeting Mitochondria 2017)
2015/06	Molecular hydrogen is a novel antioxidant to reduce oxidative stress and attenuate disease progression through modification of cell signaling and gene expressions. (15th International Conference on Oxidative Stress Reduction, Redox Homeostasis &Antioxidants)
2013	Molecular hydrogen influences gene expression profiles of rodent organs in healthy and diseased states (JOURNAL OF PHYSIOLOGICAL SCIENCES)
2012/12	Molecular hydrogen alters signaling pathways and gene expression profiles in multiple mouse organs (ASCB 2012)

Research topic, funded research, and department laboratory expense
2015/04 ～ 2018/03	Identification and functional analysis of causative genes for thymoma and muscle atrophy developing in BUF/Mna rats Grant-in-Aid for Scientific Research (C)
2012/04 ～ 2016/03	Molecular hydrogen attenuates UV-induced tissue injury in Caenorhabditis elegans and mouse Grant-in-Aid for Scientific Research (C)
2008 ～ 2010	Identification of downstream regulatory factor in RET signaling pathway and its application to cancer treatment Grant-in-Aid for Scientific Research (C)
2008 ～ 2010	New approach for health maintenanceand disease control by modification of inhaled air composition Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
2006 ～ 2007	Sprouty family of proteins regulates organogenesis and carcinogenesis through the signaling caused by RET tyrosine kinase Grant-in-Aid for Scientific Research (C)
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